Therapeutic Uses
**Treatment of anxiety disorders
**Muscle spasms
**Epileptic seizures
**Insomnia (short-term)
**Febrile convulsions in children
**Sedation before surgical procedures
Mechanism of Action
Diazepam is a benzodiazepine acting on GABA-A receptors to enhance GABAergic transmission, resulting in anxiolytic, sedative, anticonvulsant, and muscle-relaxant effects.
Precautions
**Avoid concurrent use with alcohol or CNS depressants
**Risk of dependence and addiction with prolonged use
**May cause sedation, dizziness, cognitive impairment, or paradoxical reactions
**Driving prohibited (Danger Level: Level 3)
**Not recommended in pregnancy unless medically justified
**Special caution in elderly and hepatic impairment
Abuse and Misuse
**Frequently misused for its calming and euphoric effects
**Commonly abused in combination with alcohol or opioids
**Sometimes mixed with syrup-based drinks in recreational misuse (e.g., lean)
History
**Developed by Roche in 1963
**One of the most widely prescribed benzodiazepines globally
**Initially praised for safety but now tightly regulated due to abuse potential
Additional Notes
**Prescription only
**Keep out of reach of children
**Always read the accompanying leaflet before use
Reviews
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