OxyContin®LP 40 mg(Mundipharma)🇬🇧

Ingredients
Oxycodone 40mg

Oxycontin 40 mg
OXYCONTIN is indicated for the relief of pain severe enough to require daily, long-term use of an opiate and is indicated when alternative treatment options are inadequate.

Dosage – How to use Oxycontin 40mg

Initial quantity

• OXYCONTIN should only be prescribed by a physician experienced in the use of potent opiates for the management of chronic pain.
• The initial individual dosage should be based on previous experience with pain medication and the risk of dependence, abuse, and misuse. Monitor patients closely for respiratory depression, especially during the first 24-72 hours of treatment with OXYCONTIN. OXYCONTIN tablets must be taken whole, with enough water to ensure complete swallowing. Crushing, chewing, or dissolving OXYCONTIN tablets will not control the release of oxycodone and may result in overdose or death.
• Use QXYCONTIN as your first opiate pain reliever.
• Start treatment with OXYCONTIN at a dose of 10 mg every 12 hours.

Use of OXYCONTIN in patients with opiate allergy

• The starting dose of OXYCONTIN for patients with opiate allergy is 14-10 mg every 12 hours. Patients considered opiate tolerant are those who are taking at least 60 mg/day of oral morphine, 25 mg/hour of transdermal fentanyl, 30 mg/day of oral oxycodone, 8 mg/day of oral oxycodone, 25 mg/day of oral oxymorphone, or an equivalent amount of another opiate.
• Giving high initial doses to patients with opiate allergy can cause respiratory depression, even death.

Switch from other oral oxycodone preparations to OXYCONTIN

• Patients receiving other oral oxycodone preparations may be converted to OXYCONTIN by administering half the patient’s daily oral oxycodone dose as an OXYCONTIN 12-hour tablet.

Switch from other opium to OXYCONTIN

• Discontinue other opiate pain medications when initiating OXYCONTIN therapy.
• No other method of conversion of opioids to OXYCONTIN has been established as determined by clinical trials. Discontinue other opioids when initiating OXYCONTIN therapy and administer OXYCONTIN at a starting dose of 10 mg orally every 12 hours.
• It is safer to underestimate a patient’s 24-hour oral oxycodone requirement and be prepared to administer rescue medications (such as immediate-release opiates) than to overestimate and result in a life-threatening reaction. Although opiate equivalence tables exist, there is considerable patient-to-patient variation in the relative potency of different drugs and opiate products.

Convert from methadone to OXYCONTIN

• Close monitoring is important when switching from methadone to opiate agonists, as the ratio between methadone and other opiate agonists will vary greatly with previous doses. Methadodox has a long half-life and may cause plasma accumulation.

Conversion from transdermal fentanyl to OXYCONTIN

• Eighteen hours after removal of the transdermal fentanyl patch, treatment with OXYCONTIN may be initiated. Although such a switch has not been systematically investigated, a conservative dose of oxycodone of approximately 10 mg of OXYCONTIN should be initiated every 12 hours, with transdermal fentanyl replaced every 25 mcg/hour. Closely monitor patients during the switch from transdermal fentanyl to OXYCONTIN, as only limited experience with this type of conversion has been reported.

Adjust dosage and maintain treatment

• Adjust the dose of OXYCONTIN individually to achieve a level that provides adequate pain relief and minimizes adverse events. Continue to reassess patients on OXYCONTIN to assess for maintenance of pain control and the relative incidence of adverse events, and to assess for dependence, abuse, and misuse. It is important to maintain regular communication between prescribers and other health care team members, patients, and caregivers/families throughout the course of pain medication changes, including initial adjustments. During chronic therapy, periodically reassess the need for continued use of the opiate.
• Patients with a history of acute pain may need to use increased doses of OXYCONTIN or may need to use an extended-release pain reliever. If pain levels increase after continued administration, try to identify the cause of the increased pain before increasing the dose of OXYCONTIN. Since steady-state plasma concentrations are achieved in approximately 10 days, the dose of OXYCONTIN may be adjusted every 1 to 2 days.
• If excessive opiate side effects occur, the dosage may be reduced. Adjust the dosage to achieve the appropriate balance between pain management and opiate-related side effects.
• There are no well-controlled clinical studies to evaluate the safety and effectiveness of taking more than one dose every 12 hours. As a general guideline, the total daily dose of oxycodone can be increased by 25% to 50% of the current dose, with each dose increase as clinically indicated.
• In chronic opioid therapy, particularly in non-cancer pain conditions, the need for continued opioid therapy should be assessed periodically (eg, every 6 to 12 months) as appropriate.

The patient has liver failure.

• For patients with hepatic impairment, start at 1/3 to 1/2 the usual initial dose and titrate dose carefully.

Stop using OXYCONTIN.

• When a patient does not require treatment with OXYCONTIN tablets, use a tapering regimen to avoid withdrawal symptoms and signs in physically dependent patients. Do not stop OXYCONTIN abruptly.

How to use OXYCONTIN

• Advise patients to swallow OXYCONTIN tablets whole; do not crush, dissolve, or chew tablets, as there is a risk of rapid release and absorption of a potentially fatal amount of oxycodone. Advise patients to take OXYCONTIN tablets one at a time with enough water to ensure that they swallow it immediately after it is placed in their mouth.

Drug overdose

• Seek emergency medical attention. Oxycodone overdose can be fatal.
• Symptoms of overdose may include severe drowsiness, muscle weakness, cold and clammy skin, shallow breathing, slow heart rate, fainting, or coma.

Unreceived quantity

• If you are taking this medication regularly, take it as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not take extra medication to make up the missed dose.

Contraindications of Oxycontin 40 mg

OXYCONTIN is contraindicated in patients with:

• Significant respiratory failure %
• Acute or severe bronchial asthma in untreated settings or in the absence of life-saving equipment
• Confirmed or suspected paralytic ileus and gastrointestinal obstruction
• Hypersensitivity (eg, allergic reaction) to oxycodone.

Oxycontin 40mg side effects

• Get emergency medical help if you have any signs of an allergic reaction to OxyContin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using OxyContin and call your doctor right away if you have serious side effects, such as:
• Shallow breathing, slow heart rate
• Seizures
• Cool and moist skin
• Error.
• Severe weakness or dizziness
• Less serious side effects of   OxyContin are more likely to occur, such as:
• Nausea, vomiting, constipation, loss of appetite
• Dizziness, headache, feeling tired
• Dry mouth.
• Sweating
• vehicle.
• This is not a complete list of all possible side effects and other possible side effects. Call your doctor for medical advice about side effects.

Oxycontin 40 mg drug interactions

• Do not use OxyContin with narcotic pain relievers, sedatives, sleeping pills, muscle relaxers, or other medicines that may make you drowsy or slow your breathing. Dangerous side effects could occur. Tell your doctor if you regularly take any of these medicines, epilepsy, depression, or anxiety disorders.
• Tell your doctor about all other medicines you take, especially:
• Pentazocine (talvin)
• Nalbuphine (Nuben).
• Butorphanol (Stadol).
• Buprenorphine (Buprenex, Sutex)
• This list is not complete and other drugs may interact with OxyContin. Tell your doctor about all the medications you use. This includes prescription and over-the-counter products, vitamins, and herbal products. Do not start a new medication without telling your doctor.

Beware of Oxycontin 40 mg

Drug dependence and drug misuse

• OXYCONTIN contains oxycodone, a Schedule II controlled substance. As an opiate, the use of OXYCONTIN raises concerns about the risk of addiction, abuse, and misuse. As with all modified-release products, OXYCONTIN releases the opiate over an extended period of time, creating a significant risk of overdose and death due to the large amounts of oxycodone contained.
• Although the risk of drug dependence in any individual is unknown, it can occur in any patient who receives the appropriate dose of OXYCONTIN. Drug dependence can occur at recommended doses and if the drug is misused or abused.
• Assessing each patient’s risk for opiate dependence, abuse, and misuse prior to prescribing OXYCONTIN and monitoring patients taking OXYCONTIN is routine and necessary practice. The risk of opiate use is increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or dependence) or mental illness (e.g., major depression). However, concerns about these risks should not prevent any patient from receiving appropriate pain treatment. High-risk patients can still be treated appropriately with modified-dose opiate preparations, such as OXYCONTIN, but use in these patients requires in-depth counseling about the risks and appropriate use of OXYCONTIN, with close monitoring for signs of dependence, abuse, or misuse. Use of OXYCONTIN
• Misuse or abuse of OXYCONTIN by crushing, chewing, snorting, or injecting dissolved drugs can result in uncontrolled release of the opioid into the body, potentially leading to overdose and death.
• Opiate agonists are sought after by drug addicts and those with addiction disorders and are being used illegally. Consider these risks when prescribing or dispensing the drug.
• OXYCONTIN strategies are needed to reduce these risks, including prescribing the least appropriate dose and advising patients on proper disposal of unused medication.

Life-threatening respiratory failure

• Severe, life-threatening, or fatal respiratory depression has been reported with the use of modified-release opioids, even at recommended doses. Respiratory failure, if not detected and treated promptly, can lead to respiratory arrest and death. Treatment of respiratory depression may include close observation, supportive measures, and the use of an opiate antagonist, depending on the clinical characteristics of the patient. Carbon dioxide (CO) retention, because respiratory depression caused by opioids may exacerbate the sedative effects of opioids.
• Although serious, life-threatening, or fatal respiratory depression can occur at any time during use of OXYCONTIN, the risk is greatest at the initiation of treatment or after dose increases. Monitor patients closely for signs of respiratory depression when initiating treatment with OXYCONTIN and after dose increases. To reduce the risk of respiratory depression, it is essential to administer and titrate OXYCONTIN appropriately. Overestimation of the OXYCONTIN dose when switching patients from other opioid preparations may result in a fatal overdose at the first dose.
• Accidental ingestion of a large dose of OXYCONTIN, especially in children, can cause respiratory failure and death from an oxycodone overdose.