Active ingredient
Homeopathic components
component
Oral solution
Purified Bradykinin Affinity Antibody – 0.12 g *
Purified histamine affinity antibody – 0.12 g *
Antibodies to pure morphine affinity – 0.12 g *
Ingredients: Maltitol 6.0 g, Glycerol 3.0 g, Potassium Sorbate 0.165 g, Anhydrous Citric Acid 0.02 g, Purified Water 100 ml.
* Use with isomalt in the form of a mixture of three types of water-alcohol diluents diluted in ratios of 10012, 10030 and 10050 times, respectively.
Pharmacological effects
Pharmacotherapy group, other cough medicines
Pharmacodynamics
The experimental results showed that the drug components modulate the activity of the ligand-receptor interaction of the endogenous regulator with the relevant receptors, namely, antibodies to morphine (drug components) modulate the activity of the ligand-receptor interaction of the endogenous regulator with the opioid receptor, antibodies to histamine H1 receptors, antibodies to bradykinin with bradykinin receptors. However, the combined use of the components results in an increased anti-irritant effect. In addition to the anti-irritant effect, this complex drug also has anti-inflammatory, anti-edematous, anti-allergic, anti-spasmodic (antibodies to histamine, antibodies to bradykinin) and analgesic (antibodies to morphine) effects due to the constituent components. Due to the histamine-dependent modification of the H1 receptor function, the bradykinin-dependent B1 and B2 receptor function selectively reduces the excitability of the cough center of the medulla oblongata and inhibits the coupling of the cough reflex, inhibits the pain-sensitizing center in the thalamus, blocks the transmission of pain impulses to the cerebral cortex. Inhibits the flow of pain impulses from the periphery due to a decrease in the release of carcinogens into tissues and plasma (histamine, bradykinin, prostaglandins, etc.), unlike narcotic analgesics, it is non-addictive, does not have a narcotic effect, relieves symptoms of acute pharyngitis, laryngitis and bronchitis, reduces bronchospasm, relieves systemic and local allergic reactions due to its effect on the synthesis and release of histamine and bradykinin from mast cells.
Pharmacokinetics
The sensitivity of modern physicochemical analytical methods (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) makes it impossible to assess very low levels of antibodies in body fluids, organs and tissues, which precludes the study of the pharmacokinetics of Rengalin.
Indications
Acute and chronic respiratory diseases with cough and bronchospasm, productive and non-productive cough for influenza and acute respiratory viral infections, acute pharyngitis, laryngitis, acute obstructive laryngitis, chronic bronchitis, and other infectious and allergic diseases of the upper and lower respiratory tract.
Contraindications
Children under 3 years of age, increased sensitivity to the components of the drug, hereditary fructose intolerance (due to the presence of maltitol in the composition), caution is required: diabetes.
Side effects
Possible interactions can occur if an individual is more sensitive to the components of the drug. If these side effects become more severe or you notice other side effects not listed in the instructions, please inform your doctor.
interaction
During clinical trials, no information was obtained regarding interactions between Rengalin and concomitant medications.
How to use, how to use and dosage
Take 1-2 teaspoons (5-10 ml) on an empty stomach. It is recommended to hold the solution in the mouth before swallowing for maximum effectiveness of the drug. Apply 1-2 teaspoons 3 times a day, depending on the severity of symptoms during the first 3 days. The frequency of administration can be increased up to 4-6 times a day. The duration of therapy depends on the severity of the disease and is determined by the treating physician.
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